Publications
See our latest publications below, and click on the name of each journal to read the full versions of each paper at the publishers site.
* Joint first authorship
† Joint senior authorship
Current Preprints (ahead of peer-review)
Lopes DM, Llewellyn SK, Bury SE, Wang J, Gegg M, Verona G, Lythgoe MF, Harrison IF, (2024), Influence of the Glymphatic System on -Synuclein Propagation: Role of Aquaporin-4 and the Dystrophin-Associated Protein Complex, bioRxiv, doi: https://doi.org/10.1101/2024.09.11.612272
Journal Articles
2024
Lopes DM, Wells JA, Ma D, Wallis L, Park D, Llewellyn SK, Ahmed Z, Lythgoe MF, Harrison IF, (2024), Glymphatic Inhibition Exacerbates Tau Propagation in an Alzheimers Disease Model, Alzheimer's Research & Therapy, 16 (1), 71
Evans PG, Sajic M, Yu Y, Harrison IF, Hosford PS, Smith KJ, Lythgoe MF, Stuckey DJ, Wells JA, (2024), Changes in cardiac-driven perivascular fluid movement around the MCA in a pharmacological model of acute hypertension detected with non-invasive MRI, Journal of Cerebral Blood Flow & Metabolism, 2024, 44 (4), 508-515
2022
Baker RR, Payne C, Yu Y, Mohseni M, Connell JJ, Lin F, Harrison IF, Southern P, Rudrapatna US, Stuckey DJ, Kalber TL, Siow B, Thorne L, Punwani S, Jones DK, Emberton M, Pankhurst QA, Lythgoe MF (2022), Image-Guided Magnetic Thermoseed Navigation and Tumor Ablation Using a Magnetic Resonance Imaging System, Advanced Science, Feb 2:e2105333.
2021
Perera C, Harrison IF, Lythgoe MF, Thomas DL, Wells JA, (2021), Pharmacological MRI with Simultaneous Measurement of Cerebral Perfusion and Blood-Cerebrospinal Fluid Barrier Function using Interleaved Echo-Time Arterial Spin Labelling, NeuroImage, Vol: 238, Article: 118270
Port R, Rumsby M, Brown G, Harrison IF, Amjad A, Bale C, (2021), People with Parkinson’s: what aspects of their condition do they most want to see improved and how does this change with duration?, Journal of Parkinson’s Disease, Vol:11, No: 2, Pages: 715-724
Ohene Y, Harrison IF, Evans PG, Thomas DF, Lythgoe MF, Wells JA, (2021), Increased blood-brain interface permeability to water in the ageing brain detected using non-invasive multi-TE ASL MRI, Magnetic Resonance in Medicine, Vol: 85, Issue:1, Pages: 326-333
2020
Ma D, Cardoso M, Zulluaga MA, Modat M, Powell N, Wiseman FK, Cleary JO, Sinclair B, Harrison IF, Siow B, Beg MF, Tybulewicz VLJ, Fisher EMC, Lythgoe MF, Ourselin S, (2020), Substantially thinner internal granular layer and reduced molecular layer surface in the cerebellum of the Tc1 mouse model of Down Syndrome - a comprehensive morphometric analysis with active staining contrast-enhanced MRI., NeuroImage, Vol: 223, Article: 117271
Migdalska‐Richards A, Wegrzynowicz M, Harrison IF, Verona G, Bellotti V, Spillantini MG, Schapira AH, (2020), L444P Gba1 mutation increases formation and spread of α-synuclein deposits in mice injected with mouse α-synuclein pre-formed fibrils, PLOS ONE, Volume: 15, Issue: 8, Article: e0238075
Harrison IF, Ismail O, Machhada A, Colgan N, Ohene Y, Nahavandi P, Ahmed Z, Fisher A, Meftah A, Murray TK, Ottersen OP, Negelhus EA, O'Neill MJ, Wells JA, Lythgoe MF, (2020), Impaired Glymphatic Function and Clearance of Tau in an Alzheimer’s Disease Model, Brain, Vol: 143, Issue: 8, Pages: 2576-2593
Evans PG, Sokolska M, Alves A, Harrison IF, Ohene Y, Nahavandi P, Ismail O, Miranda E, Lythgoe MF, Thomas DF, Wells JA, (2020), Non-Invasive MRI of Blood-Cerebrospinal Fluid Barrier Function, Nature Communications, Vol: 11, Issue: 1, Article: 2081
2019
Ryan SG, Butler MN, Adeyemi SS, Kalber T, Patrick PS, Thin MZ, Harrison IF, Stuckey DJ, Pule M, Lythgoe MF, (2019), Imaging of X-Ray-Excited Emissions from Quantum Dots and Biological Tissue in Whole Mouse, Scientific Reports, Vol: 9, Article: 19223
Ma D*, Holmes HE*, Cardoso MJ, Modat M, Harrison IF, Powell NM, O’Callaghan JM, Ismail O, Johnson RA, O’Neill MJ, Collins EC, Beg MF, Popuri K, Lythgoe MF, Ourselin S, (2019), Study the longitudinal in vivo and cross-sectional ex vivo brain volume difference on mouse model of tauopathy using automated MRI structural parcellation, Frontiers in Neuroscience – Brain Imaging Methods, Vol: 13, Article: 11
Harrison IF, Powell NM, Dexter DT, (2019), The Histone Deacetylase Inhibitor Nicotinamide Exacerbates Neurodegeneration in the Lactacystin Rat Model of Parkinson’s Disease, Journal of Neurochemistry, Vol: 148, Issue: 1, Pages: 136-156
Harrison IF*, Whitaker R*, Bertelli PM, O’Callaghan JM, Csincsik L, Bocchetta M, Ma D, Fisher A, Ahmed Z, Murray TK, O’Neill MJ, Rohrer JD, Lythgoe MF, Lengyel I, (2019), Optic Nerve Thinning and Neurosensory Retinal Degeneration in the rTg4510 Mouse Model of Frontotemporal Dementia, Acta Neuropathologica Communications, Vol: 7, Article: 4
Ohene Y, Harrison IF, Nahavandi P, Ismail O, Bird EV, Ottersen OP, Nagelhus EA, Thomas DL, Lythgoe MF†, Wells JA†, (2019), Non-invasive MRI of Brain Clearance Pathways using Multiple Echo Time Arterial Spin Labelling: An Aquaporin-4 Study, NeuroImage, Vol: 188, Pages: 515-523
Hadjihambi A*, Harrison IF*, Costa-Rodriguez M, Vanhaecke F, Arias N, Gallego-Duran R, Mastitskaya S, Hosford P, Olde Damink SWM, Davies N, Habtesion A, Lythgoe MF, Gourine AV†, Jalan R†, (2019), Impaired brain glymphatic flow in hepatic encephalopathy, Journal of Hepatology, Vol: 70, Issue: 1, Pages: 40-49
2018
Harrison IF, Siow B, Akilo A, Evans P, Ismail O, Ohene Y, Nahavandi P, Thomas DL, Lythgoe MF, Wells JA, (2018), Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI, eLife, Vol: 7, Article: e34028
Harrison IF, Smith AD, Dexter DT, (2018), Pathological Histone Acetylation in Parkinson’s Disease: Neuroprotection and Inhibition of Microglial Activation Through SIRT 2 Inhibition, Neuroscience Letters, Vol: 666, Pages: 48-57
2017
Colgan N, Ganeshan B, Harrison IF, Holmes HE, Ismail O, Powell N, O’Callaghan JM, Murray TK, Ahmed Z, Johnson RA, Collins EC, O’Neill MJ, Groves A, Lythgoe MF, (2017), In vivo Imaging of Tau Pathology using Magnetic Resonance Imaging Textural Analysis, Frontiers in Neuroscience - Brain Imaging Methods, Vol: 11, Article: 599
O’Callaghan J, Holmes H, Powell N, Wells JA, Ismail O, Harrison IF, Siow B, Johnson R, Ahmed Z, Fisher A, Meftah S, O’Neill MJ, Murray TK, Collins EC, Lythgoe MF, (2017), Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer’s disease, NeuroImage, Vol: 159, Pages: 334-345
Holmes HE*, Powell NM*, Ma D, Harrison IF, Wells JA, Colgan N, Ismail O, O’Callaghan JM, Murray TK, O’Neill MJ, Collins EC, Cardoso J, Modat M, Fisher EMC, Ourselin S, Lythgoe MF, (2017), Comparison of in vivo and ex vivo MRI for the detection of structural abnormailities in a mouse model of tauopathy, Frontiers in Neuroinformatics, Vol: 11(20), Article: 20
2016
Harrison IF, Anis H, Dexter DT, (2016), Associated Degeneration of Ventral Tegmental Area Dopaminergic Neurons in the Rat Nigrostriatal Lactacystin Model of Parkinsonism and their Neuroprotection by Valproate, Neuroscience Letters, Vol: 614, Pages: 16-23
Holmes HE*, Colgan N*, Ismail O, Ma D, Powell NM, O’Callaghan JM, Harrison IF, Johnson RA, Murray TK, Ahmed Z, Heggenes M, Fisher A, Cardoso J, Modat M, Walker-Samuel S, Fisher EMC, Ourselin S, O’Neill MJ, Wells JA, Collins EC, Lythgoe MF, (2016), Imaging the Accumulation and Suppression of Tau Pathology using Multi-Parametric MRI, Neurobiology of Aging, Vol: 39, Pages: 184-194
Colgan N*, Siow B*, O’Callaghan JM, Harrison IF, Wells JA, Holmes HE, Ismail O, Richardson S, Alexander DC, Collins EC, Johnson R, Schwarz AJ, Ahmed Z, O’Neill MJ, Murray TK, Zhang H†, Lythgoe MF†, (2016), Application of neurite orientation dispersion and density imaging to a tau pathology model of Alzheimer’s disease, NeuroImage, Vol: 125, Pages: 739-744
2015
Harrison IF, Crum WR, Vernon AC, Dexter DT, (2015), Neurorestoration Induced by the HDAC Inhibitor Sodium Valproate in the Lactacystin Model of Parkinson’s is Associated with Histone Acetylation and Upregulation of Neurotrophic Factors, British Journal of Pharmacology, Vol: 172(16), Pages: 4200-4215
Di Fruscia P, Zacharioudakis E, Liu C, Moniot S, Laohasinnarong S, Khongkow M, Harrison IF, Koltsida K, Reynolds CR, Schmidtkunz K, Jung M, Chapman KL, Steegborn C, Dexter DT, Sternberg MSE, Lam EW-F, Fuchter MJ, (2015), The Discovery of a Highly Isoform Selective 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 Inhibitor that is Neuroprotective in an in vitro Parkinson’s Disease Model, ChemMedChem, Vol: 10, Pages: 69-82
Pienaar IS, Harrison IF, Elson JL, Bury A, Woll P, Simon AK, Dexter DT, (2015), An animal model mimicking pedunculopontine nucleus cholinergic degeneration in Parkinson's disease, Brain Structure & Function, Vol: 220(1), Pages: 479-500
2013
Katsouri L, Vizcaychipi MP, McArthur S, Harrison IF, Suárez-Calvet M, Lleo A, Lloyd DG, Ma D, Sastre M, (2013), Prazosin, an alpha(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease, Neurobiology of Aging, Vol: 34(4), Pages: 1105-1115
Review Articles
Lopes DM, Llewellyn SK, Harrison IF, (2022), Propagation of tau and alpha-synuclein in the brain: therapeutic potential of the glymphatic system. Translational Neurodegeneration. Mar 21;11(1):19
Harrison IF, Dexter DT, (2013), Epigenetic Targeting of Histone Deacetylase: Therapeutic Potential in Parkinson's Disease? Pharmacology & Therapeutics, Vol: 140, Pages: 34-52
Book Chapters
Harrison IF, Wells JA, Lythgoe MF, (2018), Experimental Models of Brain Disease: MRI Studies, In Modern Magnetic Resonance, 2nd Edition, edited by Graham Webb, ISBN: 978-3-319-28275-6, Pages 93-120.